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News Physiol Sci 1: 12-15, 1986;
1548-9213/86 $5.00
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News in Physiological Sciences, Vol 1, 12-15, Copyright © 1986 by International Union of Physiological Sciences

ARTICLES

Putrescine, Spermidine, and Spermine

H Olle

Putrescine was first isolated from putrifying meat and was thought of as a decomposition product;spermine was named from its occurrence in semen. These polyamines, however, are now known to have important roles in cell growth and differentiation. Their physiological significance can be studied by analyzing the consequences of depletion of the cellular polyamine content. The results include arrest of cell growth, differentiation, and division. Further results suggest that blocking of polyamine synthesis may have broad implications in clinical medicine.




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