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News Physiol Sci 1: 107-109, 1986;
1548-9213/86 $5.00
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News in Physiological Sciences, Vol 1, 107-109, Copyright © 1986 by International Union of Physiological Sciences

ARTICLES

The Cholinergic Connection in Alzheimer's Disease

M-M Mesulam

Alzheimer's disease is a failure of physiological function at the highest level of integration in the nervous system. Until now, information about the basis of this disease has come mostly from anatomical and neurochemical studies that implicate several transmitter systems, especially the forebrain cholinergic projection. This up-to-date review should help convey the need for physiological studies of the forebrain transmitter system in animal models of aging and degeneration.




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