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News Physiol Sci 1: 119-122, 1986;
1548-9213/86 $5.00
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News in Physiological Sciences, Vol 1, 119-122, Copyright © 1986 by International Union of Physiological Sciences

ARTICLES

Brown Adipose Tissue: An Extrathyroidal Source of Triiodothyronine

JE Silva

The role of brown adipose tissue in heat production is well known, but it is a novel concept that this tissue can activate the main secretory product of the thyroid gland, thyroxine, by converting it into the ten times more active triiodothyronine. The enzyme that catalyzes the reaction is present also in other tissues, but it is activated by the sympathetic nervous system only in brown adipose tissue. Thus sympathetic stimulation of brown adipose tissue results in increased production of triiodothyronine and activation of metabolism in other tissues.




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