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News Physiol Sci 10: 22-29, 1995;
1548-9213/95 $5.00
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News in Physiological Sciences, Vol 10, 22-29, Copyright © 1995 by International Union of Physiological Sciences

ARTICLES

Glucose Transport and Glucose Homeostasis: New Insights From Transgenic Mice

MM Mueckler

Experiments with transgenic mice overexpressing glucose transporter isoforms demonstrate the preeminence of the transport step with respect to muscle glucose disposal and whole body glucose homeostasis. These studies suggest the feasibility of controlling diabetic hyperglycemia by pharmacological or genetic enhancement of muscle glucose transport.


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