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News Physiol Sci 10: 6-12, 1995;
1548-9213/95 $5.00
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News in Physiological Sciences, Vol 10, 6-12, Copyright © 1995 by International Union of Physiological Sciences


ARTICLES

Mechanical Modulation of the Ca2+ Regulatory Protein Complex in Cardiac Muscle

F Fuchs

The regulatory protein complex of cardiac myofilaments not only mediates Ca2+ activation of cross-bridge cycling but serves as a pathway through which changes in load or length can modify Ca2+ regulation. This mechanical feedback may be an important component of the steep force-length relationship in the myocardium.


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