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News Physiol Sci 10: 101-106, 1995;
1548-9213/95 $5.00
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News in Physiological Sciences, Vol 10, 101-106, Copyright © 1995 by International Union of Physiological Sciences

ARTICLES

Using Antibodies to unwire the Sympathetic Nervous System

S Brimijoin

Antibodies to surface antigens can target specific neuronal populations for destruction, sometimes with surprising results. In rats, for example, antibodies to the widely distributed synaptic enzyme acetylcholinesterase cause selective ablation of preganglionic sympathetic terminals. This phenomenon is relevant to autonomic disorders of human patients and may also yield insights into normal autonomic physiology.




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