Physiology AJP: Regulatory, Integrative and Comparative Physiology
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News Physiol Sci 10: 198-204, 1995;
1548-9213/95 $5.00
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News in Physiological Sciences, Vol 10, 198-204, Copyright © 1995 by International Union of Physiological Sciences

ARTICLES

Controlling the Nongenomic Actions of 1,25 (OH)2D3

MC Farach-Carson and RE Devoll

1a, 25-Dihydroxyvitamin D3 [1,25(OH)2D3] is a potential therapeutic agent for treatment of many clinical disorders, but its tendency to produce hypercalcemia at therapeutic dosages is a barrier to its usefulness. Derivatives of 1,25(OH)2D3 have been synthesized that possess the beneficial genomic activities of 1,25(OH)2D3 but have reduced nongenomic effects, which may be correlated with a tendency to produce hypercalcemia.


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R. Liu, W. Li, N. J. Karin, J. J. Bergh, K. Adler-Storthz, and M. C. Farach-Carson
Ribozyme Ablation Demonstrates That the Cardiac Subtype of the Voltage-sensitive Calcium Channel Is the Molecular Transducer of 1,25-Dihydroxyvitamin D3-stimulated Calcium Influx in Osteoblastic Cells
J. Biol. Chem., March 17, 2000; 275(12): 8711 - 8718.
[Abstract] [Full Text] [PDF]


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