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News in Physiological Sciences, Vol 10, 211-216, Copyright © 1995 by International Union of Physiological Sciences
ARTICLES |
H Acker and D Xue
An NAD(P)H oxidase-generating H2O2 dependent on PO2 is proposed as an O2 sensor protein in type I cells of the carotid body, regulating potassium channel open probability as well as tyrosine hydroxylase gene expression. The proposed signal cascade also is important in other O2-sensing cells.
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