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News Physiol Sci 10: 228-233, 1995;
1548-9213/95 $5.00
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News in Physiological Sciences, Vol 10, 228-233, Copyright © 1995 by International Union of Physiological Sciences

ARTICLES

Role of Endothelin in Central Cardiorespiratory Control: Modern and Classical Approaches

T Kuwaki, Y Kurihara, H Kurihara, Y Yazaki and M Kumada

Mutant mice deficient in endothelin-1 (ET-1) were created by using gene-targeting techniques. ET-1 +/- heterozygous mice showed elevated arterial pressure accompanied by diminished arterial PO2 and impaired respiratory reflexes. Endogenous ET-1 thus plays a physiological role in cardiorespiratory control. Neural structures in the ventral medulla oblongata appear to participate in this process.


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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. Kurihara, H. Kurihara, H. Morita, W.-H. Cao, G.-Y. Ling, M. Kumada, S. Kimura, R. Nagai, Y. Yazaki, and T. Kuwaki
Role of endothelin-1 in stress response in the central nervous system
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2000; 279(2): R515 - R521.
[Abstract] [Full Text] [PDF]


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