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News Physiol Sci 10: 233-238, 1995;
1548-9213/95 $5.00
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News in Physiological Sciences, Vol 10, 233-238, Copyright © 1995 by International Union of Physiological Sciences

ARTICLES

How and Why Cells Make Superoxide: The "Phagocytic" NADPH Oxidase

FE Maly and CC Schurer-Maly

The phagocyte enzyme NADPH oxidase generates superoxide essential for antimicrobial defense;its genetic defects cause the immunodeficiency disorder chronic granulomatous disease. B lymphocytes and certain other nonphagocytes also express NADPH oxidase. Molecular approaches allow new ways to study the enzyme and promise to uncover why nonphagocytic cells express NADPH oxidase.




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