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News Physiol Sci 10: 247-253, 1995;
1548-9213/95 $5.00
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News in Physiological Sciences, Vol 10, 247-253, Copyright © 1995 by International Union of Physiological Sciences

ARTICLES

Does the Heart's Hormone, ANP, Help in Congestive Heart Failure?

J Winaver, A Hoffman, Z Abassi and A Haramati

In congestive heart failure, increased secretion of atrial natriuretic peptide (ANP) is an important compensatory mechanism that unloads the failing heart and promotes renal salt and water excretion. However, activation of opposing sodium-retaining factors, particularly the renin-angiotensin system, reduces renal responsiveness to ANP and shifts the cardiovascular system to a state of decompensation.


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