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News Physiol Sci 10: 260-265, 1995;
1548-9213/95 $5.00
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News in Physiological Sciences, Vol 10, 260-265, Copyright © 1995 by International Union of Physiological Sciences


ARTICLES

Neural Mechanisms of Hyperalgesia: Peripheral or Central Sensitization?

E Carstens

Everyone has experienced soreness after an injury. What neural processes underlie this increased pain sensitivity (hyperalgesia)? Recent data indicate that injury triggers an increase in the sensitivity of spinal cord pain-signaling neurons. Nonpainful activation of these sensitized neurons evokes an exaggerated signal interpreted as pain.


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