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News in Physiological Sciences, Vol 11, 17-24, Copyright © 1996 by International Union of Physiological Sciences
ARTICLES |
LR Forte and FK Hamra
Guanylin and uroguanylin are peptides that activate a membrane guanylate cyclase and control salt and water transport. Intestinal bacteria secrete toxins that mimic the actions of these peptides, causing a secretory form of diarrhea. Stimulation of guanylin/uroguanylin receptors in the kidney increases salt excretion. Thus guanylin and uroguanylin may regulate salt and water homeostasis.
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