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News Physiol Sci 11: 72-77, 1996;
1548-9213/96 $5.00
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News in Physiological Sciences, Vol 11, 72-77, Copyright © 1996 by International Union of Physiological Sciences

ARTICLES

Temperature and Proteins: Little Things Can Mean a Lot

GN Somero

Protein structures are highly sensitive to temperature because their net free energies of stabilization are low, about equal to energies associated with formation of a few noncovalent ("weak") bonds. Temperature-adaptive changes in protein stability and fucntion may result from minor changes in amino acid sequence at regions outside active sites and from accumulation of stabilizing solutes in the cell.


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