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News Physiol Sci 11: 77-82, 1996;
1548-9213/96 $5.00
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News in Physiological Sciences, Vol 11, 77-82, Copyright © 1996 by International Union of Physiological Sciences

ARTICLES

Molecular Basis for Functional Differences of AMPA-Subtype Glutamate Receptors

S Ozawa and J Rossier

To trace the molecular basis of functional properties of native a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors, we have coupled patch-clamp recordings and reverse transcription followed by polymerase chain reaction amplification. AMPA receptors lacking the GluR2 subunit in a population of hippocampal neurons exhibited a strong inward rectification and were highly permeable to Ca2+.




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