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News Physiol Sci 11: 157-161, 1996;
1548-9213/96 $5.00
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News in Physiological Sciences, Vol 11, 157-161, Copyright © 1996 by International Union of Physiological Sciences

ARTICLES

Species Specificity of the Primate Growth Hormone Receptor

HM Goodman, GP Frick and S Souza

Unlike other mammals, primates can respond to growth hormone (GH) only of primate origin. This species specificity results from the incompatibility of the positively charged arginine found uniquely in primate GH receptors with histidine in the GH molecules in all nonprimates in place of the aspartate found in primate GHs.




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