Physiology AJP: Heart and Circulatory Physiology
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News Physiol Sci 11: 166-170, 1996;
1548-9213/96 $5.00
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News in Physiological Sciences, Vol 11, 166-170, Copyright © 1996 by International Union of Physiological Sciences

ARTICLES

Myocardial Hibernation: Adaptation to Ischemia

G Heusch and R Schulz

As long as myocardial blood flow, following a sudden reduction, remains above 30% of baseline, the myocardium can adapt to ischemia, i.e., recover metabolically, remain viable, and increase its contractile function during inotropic stimulation. This adaptive response to ischemia is termed "hibernation". The detailed mediators of such adaptation are unknown at present.


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