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News Physiol Sci 11: 249-255, 1996;
1548-9213/96 $5.00
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News in Physiological Sciences, Vol 11, 249-255, Copyright © 1996 by International Union of Physiological Sciences

ARTICLES

Role of Parvalbumin in Skeletal Muscle Relaxation

JA Rall

Parvalbumin, a soluble intracellular calcium buffer, is present in high concentrations in fast-contracting skeletal muscles across the animal kingdom. In frog skeletal muscle, pharmacological or low-temperature inhibition of the sarcoplasmic reticulum calcium pump reveals that parvalbumin sequesters calcium and promotes relaxation at a rate determined by magnesium dissociation from parvalbumin.


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