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News Physiol Sci 11: 255-261, 1996;
1548-9213/96 $5.00
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News in Physiological Sciences, Vol 11, 255-261, Copyright © 1996 by International Union of Physiological Sciences

ARTICLES

Mechanisms of Obesity-Induced Hypertension

JE Hall, DH Zappe, M Alonso-Galicia, JP Granger, MW Brands and SE Kassab

Obesity is a major cause of human essential hypertension. Recent studies point toward increased renal tubular reabsorption and abnormal renal pressure natriuresis in mediating obesity hypertension. The mechanisms for these renal changes appear to be multifactorial, including activation of the sympathetic nervous system and altered intrarenal histology, which compresses the renal medulla.


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