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News Physiol Sci 12: 21-31, 1997;
1548-9213/97 $5.00
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News in Physiological Sciences, Vol 12, 21-31, Copyright © 1997 by International Union of Physiological Sciences

ARTICLES

Barriers in the Developing Brain

NR Saunders and KM Dziegielewska

Evidence is summarized that shows that proteins do not penetrate into immature brain. Some proteins reach cerebrospinal fluid (CSF) from plasma by a developmentally regulated transfer mechanism. There are also barriers at CSF-brain interfaces, not present in the adult. Thus there is specialization of barriers in the developing brain, some being unique to fetuses.




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