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News Physiol Sci 12: 78-83, 1997;
1548-9213/97 $5.00
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News in Physiological Sciences, Vol 12, 78-83, Copyright © 1997 by International Union of Physiological Sciences

ARTICLES

Role of Cardiac KATP Channels During Anoxia and Ischemia

K Benndorf, S Thierfelder, B Doepner, C Gebhardt and H Hirche

In isolated heart cells, maintained anoxia causes a transient opening of KATP channels. In the ischemic myocardium, this extra K+ conductance results in a decreased contractility and may be arrhythmogenic. Recent studies provide further evidence that the transient activity of KATP channels during anoxia is correlated with the time course of extracellular K+ accumulation during ischemia.


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