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News Physiol Sci 12: 117-121, 1997;
1548-9213/97 $5.00
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News in Physiological Sciences, Vol 12, 117-121, Copyright © 1997 by International Union of Physiological Sciences

ARTICLES

Novel Kinase Signaling Cascades in Pancreatic Acinar Cells

JA Williams, A Dabrowski and CD Logsdon

Pancreatic secretagogues that activate digestive enzyme secretion through classic intracellular mediators such as Ca2+ also activate novel signaling kinase cascades. The best defined of these is the MAP kinase cascade, but cholecystokinin also activates jun kinase, p38 MAP kinase, and S6 kinase. These novel pathways are likely involved with pancreatic growth and gene expression.


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[Abstract] [Full Text] [PDF]


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