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News Physiol Sci 12: 136-141, 1997;
1548-9213/97 $5.00
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News in Physiological Sciences, Vol 12, 136-141, Copyright © 1997 by International Union of Physiological Sciences

ARTICLES

GABAC Receptors: A Novel Receptor Family with Unusual Pharmacology

E Cherubini and F Strata

GABAC-receptor channels constitute a novel class of structurally defined receptors that are composed by the recently discovered r-subunits. They conduct chloride ions, are insensitive to both bicuculline and baclofen, and are blocked by picrotoxin. They are present in the hippocampus during development and in the retina where they play a crucial role in regulating visual processing.




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