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News in Physiological Sciences, Vol 12, 178-184, Copyright © 1997 by International Union of Physiological Sciences
ARTICLES |
RJ Wiesner
Training of skeletal muscle, as well as thyroid and steroid hormones, stimulates mitochondrial biogenesis, which requires regulation of genes encoded on nuclear and mitochondrial DNA. Imbalances between energy demand and supply increase mitochondrial gene expression via as yet unknown metabolic signals involving transcription factors in the sense of a negative feedback loop.
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