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News Physiol Sci 12: 197-203, 1997;
1548-9213/97 $5.00
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News in Physiological Sciences, Vol 12, 197-203, Copyright © 1997 by International Union of Physiological Sciences

ARTICLES

Nature's KATP-Channel Knockout

MJ Dunne, A Aynsley-Green and KJ Lindley

We describe here how ion-channel dysfunction in b-cells is associated with the pathogenesis of a potentially lethal condition in newborn children and early infancy. We review how nature's KATP-channel knockout has important medical implications and how key lessons in physiology can be learned from studies of rare diseases.


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