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News Physiol Sci 12: 203-210, 1997;
1548-9213/97 $5.00
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News in Physiological Sciences, Vol 12, 203-210, Copyright © 1997 by International Union of Physiological Sciences

ARTICLES

How Does an Ion Channel Sense Voltage?

DM Papazian and F Bezanilla

Voltage-dependent ion channels underlie nerve and muscle excitability. Recent studies have increased our understanding of how voltage controls channel activity. Charged residues in transmembrane segments that contribute to the voltage sensor have been identified. During activation, voltage-sensing residues traverse a significant fraction of the transmembrane electric field, dramatically increasing the probability that the channel will enter an open, ion-conducting state.


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