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News Physiol Sci 12: 214-218, 1997;
1548-9213/97 $5.00
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News in Physiological Sciences, Vol 12, 214-218, Copyright © 1997 by International Union of Physiological Sciences

ARTICLES

HIF-1, a Mediator of the Molecular Response to Hypoxia

M Gassmann and RH Wenger

Normal oxygen delivery is essential for vertebrate homeostasis. Adaptation to changes in oxygen supply involves complex but specific changes in gene expression. This review summarizes recent information on the molecular anatomy and physiology of the first hypoxia-inducible transcription factor (HIF-1) discovered in mammals. Identifications of HIF-1 provides an important tool for investigating oxygen-sensing and signaling mechanisms.


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