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News Physiol Sci 12: 249-254, 1997;
1548-9213/97 $5.00
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News in Physiological Sciences, Vol 12, 249-254, Copyright © 1997 by International Union of Physiological Sciences

ARTICLES

Motions of Myosin Heads That Drive Muscle Contraction

M Irving and G Piazzesi

Muscle contraction is driven by the interaction of the head domain of myosin with the actin filament, coupled to the hydrolysis of ATP. Recent experiments on isolated muscle cells have shown that rotation of the myosin heads with respect to the filament axis is directly linked to force generation.


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