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News Physiol Sci 12: 263-268, 1997;
1548-9213/97 $5.00
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News in Physiological Sciences, Vol 12, 263-268, Copyright © 1997 by International Union of Physiological Sciences

ARTICLES

Cholecystokinin Type A and Type B Receptors and Their Modulation of Opioid Analgesia

F Benedetti

Several lines of evidence indicate that cholecystokinin (CCK) antagonists potentiate analgesia induced by exogenous opioids. Similarly, CCK antagonists enhance analgesia induced by procedures that activate endogenous opioid systems. However, because there are substantial species differences in receptor specificity and distribution, the role of CCK type A and type B receptors has yet to be clearly established.


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