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Structure and Function of Renal Organic Cation Transporters

Hermann Koepsell, Andreas Busch, Valentin Gorboulev and Petra Arndt

H. Koepsell, V. Gorboulev, and P. Arndt are at the Institute of Anatomy, University of Würzburg, Koellikerstr. 6, 97070 Würzburg, Germany; A. Busch at the Institute of Physiology, University of Tübingen, Gmelinstr. 5, 72076 Tübingen, Germany.
Polyspecific transport systems in the kidney mediate the excretion and reabsorption of organic cations. Electrogenic import systems and electroneutral export systems in the basolateral and luminal plasma membranes of proximal renal tubules are involved. Two subtypes of electrogenic import systems have been cloned from rats and humans and functionally characterized.

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