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Killing Mechanisms of Cytotoxic T Lymphocytes

Peter Groscurth and Luis Filgueira

P. Groscurth and L. Filgueira are in the Division of Cell Biology, Institute of Anatomy, University of Zürich-Irchel, Winterhurerstrasse 190, CH-8057 Zurich, Switzerland.
Cytotoxic T lymphocytes mediate lysis of target cells by various mechanisms, including exocytosis of lytic proteins (perforin, granzymes) and receptor-ligand binding of Fas/APO molecules. Death of target cells is characterized by either necrosis or apoptosis, depending on the killing mechanism used and on the metabolism of the target cell itself.

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