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News Physiol Sci 13: 38-43, 1998;
1548-9213/98 $5.00
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News in Physiological Sciences, Vol. 13, No. 1, 38-43, February 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

Understanding the Role of Paracellular Transport in the Proximal Tubule

Néstor H. García, Carla R. Ramsey and Franklyn G. Knox

N. H. García, C. R. Ramsey and F. G. Knox are in the Nephrology Research Unit, Depts of Medicine and Physiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Fluid and solute reabsorption by the proximal tubule is the result of both transcellular and paracellular flux. The role of transcellular transport has been extensively studied, but the importance of paracellular flux has not been as thoroughly investigated. The purpose of this review is to update concepts about the contribution of paracellular transport for reabsorption by the proximal tubule.




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