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News Physiol Sci 13: 44-50, 1998;
1548-9213/98 $5.00
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News in Physiological Sciences, Vol. 13, No. 1, 44-50, February 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

Ion Permeability of the Nuclear Envelope

Michele Mazzanti

M. Mazzanti is in the Dipartimento di Fisiologia e Biochimica Generali, Laboratorio di Elettrofisiologia, Universita degli Studi di Milano, via Celoria 26, I-20133 Milan, Italy.
The nuclear envelope mediates nucleocytoplasmic communication. Nuclear pores transport proteins and RNA into and out of the nucleus. The pore is believed to allow free ion diffusion. Using an electrophysiological approach, we show the possible semipermeable properties of the envelope. To accomplish these functions we hypothesize a mechanism in which the pore complex acts as a molecular diaphragm.




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R. TONINI, F. GROHOVAZ, C. A. M. LAPORTA, and M. MAZZANTI
Gating mechanism of the nuclear pore complex channel in isolated neonatal and adult mouse liver nuclei
FASEB J, August 1, 1999; 13(11): 1395 - 1403.
[Abstract] [Full Text]




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