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News Physiol Sci 13: 5-11, 1998;
1548-9213/98 $5.00
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News in Physiological Sciences, Vol. 13, No. 1, 5-11, February 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

Renal Proximal Tubular Albumin Reabsorption: Daily Prevention of Albuminuria

Michael Gekle

M. Gekle is in the Physiologisches Institut, Universität Würzburg, Röntgenring 9, 97070 Würzburg, Germany.
Although the glomerular filtration coefficient of albumin is small, the daily filtered load can be as much as 8 g. To prevent such massive losses of albumin, quantitative reabsorption along the proximal tubules is accomplished by "receptor"-mediated endocytosis. Albumin reaches the lysosomes where it is degraded to amino acids.




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