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News Physiol Sci 13: 58-63, 1998;
1548-9213/98 $5.00
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News in Physiological Sciences, Vol. 13, No. 2, 58-63, April 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins

Charalabos Pothoulakis, Ignazio Castagliuolo and J. Thomas LaMont

C. Pothoulakis, I. Castagliuolo, and J. T. LaMont are in the Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston MA 02215, USA.
Experiments in intact animals exposed to enterotoxins demonstrate that neurons and immune cells of the lamina propria regulate toxin-induced diarrhea and tissue damage. Clostridium difficile toxins cause profound diarrhea and acute inflammation by activating a complex cascade initiated by toxin binding to enterocyte receptors.




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