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D. P. Wolfer, M. Stagljar-Bozicevic, and H.-P. Lipp are from the Laboratory of Neuroanatomy and Behavior, Institute of Anatomy, University of Zürich, CH-8057 Zürich, Switzerland; M. L. Errington is from the Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London, UK.
Spatial learning of transgenic mice is often assessed in the Morris watermaze, where mice must use distant cues to locate a submerged platform. Such learning is confounded by species-specific noncognitive swimming strategies. Factor analysis permits cognitive and noncognitive strategies to be disentangled and their association with electrophysiological phenomena to be investigated.
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