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News Physiol Sci 13: 123-131, 1998;
1548-9213/98 $5.00
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News in Physiological Sciences, Vol. 13, No. 3, 123-131, June 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

The Molecular Physiology of Sodium- and Proton-Coupled Solute Transporters

Angela Steel and Matthias A. Hediger

M. A. Hediger is in the Harvard Institutes of Medicine, 77 Ave. Louis Pasteur, Rm. 570, Boston, MA 02115, USA (E-mail: mhediger{at}rics.bwh.harvard.edu). A. Steel is at SmithKline Beecham Pharmaceuticals, 1250 S. Collegeville Rd., Collegeville, PA 19426-0989, USA.
The expression of cloned Na+- and H+-coupled solute transporters in Xenopus laevis oocytes has permitted detailed molecular and biophysical analysis and illuminated unique mechanistic features. The identification of missense mutations in inherited diseases and site-directed mutagenesis studies have enhanced our understanding of their roles in physiological and pathological processes.




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