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News Physiol Sci 13: 131-137, 1998;
1548-9213/98 $5.00
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News in Physiological Sciences, Vol. 13, No. 3, 131-137, June 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

Functional Modulation of Cardiac ATP-Sensitive K+ Channels

Masayasu Hiraoka and Tetsushi Furukawa

M. Hiraoka is in the Dept. of Cardiovascular Diseases and T. Furukawa is in the Dept. of Autonomic Physiology of the Medicalcal Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113 Japan.
ATP-sensitive K+ (KATP) channels are inhibited by intracellular ATP, but MgATP is necessary to maintain the channel activity. Numerous cofactors modulate channel function. K+ channel openers activate and sulfonylureas inhibit KATP channels. The structure of cardiac KATP channel is a complex of mainly KIR6.2 and SUR2a. Activation of cardiac KATP channels contributes to action potential shortening during ischemia and plays a role in cardioprotection.




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