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J. R. Holda, A. Klishin, M. Sedova, J. Hüser, and L. A. Blatter are in the Dept. of Physiology and the Cardiovascular Institute, Loyola University Chicago, Stritch School of Medicine, 2160 South First Ave., Maywood, IL 60153, USA.
Capacitative Ca2+ entry is a recently discovered Ca2+ entry pathway that is activated on depletion of intracellular Ca2+ stores, providing an avenue for store refilling. Despite recent progress in elucidating the capacitative Ca2+ entry pathway, the mysteries of its molecular identity, its biophysical properties, and the store depletion signal remain.
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