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Ethanol: Novel Actions on Nerve Cell Physiology Explain Impaired Functions

Esa R. Korpi, Riikka Mäkelä and Mikko Uusi-Oukari

E. R. Korpi and M. Uusi-Oukari are from the Department of Pharmacology and Clinical Pharmacology, University of Turku, FIN-20520 Turku, Finland, and R. Mäkelä is from the Tampere Brain Research Center, University of Tampere Medical School, Tampere, and the Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland.
Molecular biological tools have revealed receptor proteins for excitatory and inhibitory neurotransmitters on cell membranes as targets of ethanol action. Behavioral and pharmacogenetic assays using rodent lines have supported this neurotransmitter theory of ethanol action and given a firm basis for future identification of the relevant genes and the central physiological processes vulnerable to ethanol.

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