Physiology Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

News Physiol Sci 13: 170-176, 1998;
1548-9213/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Navar, L. G.
Right arrow Articles by Mitchell, K. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Navar, L. G.
Right arrow Articles by Mitchell, K. D.
News in Physiological Sciences, Vol. 13, No. 4, 170-176, August 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

Unraveling the Mystery of Goldblatt Hypertension

L. Gabriel Navar, Lixian Zou, Annette Von Thun, Chi Tarng Wang, John D. Imig and Kenneth D. Mitchell

L. G. Navar, J. D. Imig, and K. D. Mitchell are in the Dept. of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA; L. Zou was a Postdoctoral Fellow in that Department. A. Von Thun is in the Dept. of Internal Medicine of the Naval Medical Center, San Diego, CA, USA. C. T. Wang is in the Dept. of Internal Medicine, Section of Nephrology, General Hospital, Taipei, Taiwan.
In hypertension caused by unilateral renal artery stenosis, the nonstenotic kidney becomes renin depleted but fails to prevent hypertension. The nonstenotic kidney mysteriously develops elevated intrarenal angiotensin II (ANG II) content. Rats chronically infused with ANG II exhibit a similar hypertensive process. The augmentation of intrarenal ANG II is due to receptor-mediated internalization and continued ANG II formation, which provide a hypertensinogenic stimulus.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. M. Bivol, M. Hultstrom, O. A. Gudbrandsen, R. K. Berge, and B. M. Iversen
Tetradecylthioacetic acid downregulates cyclooxygenase 2 in the renal cortex of two-kidney, one-clip hypertensive rats
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1866 - R1873.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. M. Harris, H. I. Cohn, S. Pesant, R.-H. Zhou, and A. D. Eckhart
Vascular smooth muscle Gq signaling is involved in high blood pressure in both induced renal and genetic vascular smooth muscle-derived models of hypertension
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3072 - H3079.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. M. Bivol, R. K. Berge, and B. M. Iversen
Differential effect of tetradecythioacetic acid on the renin-angiotensin system and blood pressure in SHR and 2-kidney, 1-clip hypertension
Am J Physiol Renal Physiol, September 1, 2007; 293(3): F839 - F845.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
X. C. Li, O. A. Carretero, L. G. Navar, and J. L. Zhuo
AT1 receptor-mediated accumulation of extracellular angiotensin II in proximal tubule cells: role of cytoskeleton microtubules and tyrosine phosphatases
Am J Physiol Renal Physiol, August 1, 2006; 291(2): F375 - F383.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. L. Zhuo, X. C. Li, J. L. Garvin, L. G. Navar, and O. A. Carretero
Intracellular ANG II induces cytosolic Ca2+ mobilization by stimulating intracellular AT1 receptors in proximal tubule cells
Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1382 - F1390.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
K. K. Al-Qattan, M. Thomson, S. Al-Mutawa'a, D. Al-Hajeri, H. Drobiova, and M. Ali
Nitric Oxide Mediates the Blood-Pressure Lowering Effect of Garlic in the Rat Two-Kidney, One-Clip Model of Hypertension
J. Nutr., March 1, 2006; 136(3): 774S - 776S.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
R. M.P. Arruda, V. A. Peotta, S. S. Meyrelles, and E. C. Vasquez
Evaluation of Vascular Function in Apolipoprotein E Knockout Mice With Angiotensin-Dependent Renovascular Hypertension
Hypertension, October 1, 2005; 46(4): 932 - 936.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Hiyoshi, K. Yayama, M. Takano, and H. Okamoto
Angiotensin Type 2 Receptor-Mediated Phosphorylation of eNOS in the Aortas of Mice With 2-Kidney, 1-Clip Hypertension
Hypertension, May 1, 2005; 45(5): 967 - 973.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
L. Cervenka, V. Horacek, I. Vaneckova, J. A. Hubacek, M. I. Oliverio, T. M. Coffman, and L. G. Navar
Essential Role of AT1A Receptor in the Development of 2K1C Hypertension
Hypertension, November 1, 2002; 40(5): 735 - 741.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. L. Zhuo, J. D. Imig, T. G. Hammond, S. Orengo, E. Benes, and L. G. Navar
Ang II Accumulation in Rat Renal Endosomes During Ang II-Induced Hypertension: Role of AT1 Receptor
Hypertension, January 1, 2002; 39(1): 116 - 121.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S. M. Galli and M. I. Phillips
Angiotensin II AT1A Receptor Antisense Lowers Blood Pressure in Acute 2-Kidney, 1-Clip Hypertension
Hypertension, September 1, 2001; 38(3): 674 - 678.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online