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Fast Inactivation of Voltage-Gated K⁺ Channels: From Cartoon to Structure

Christoph Antz and Bernd Fakler

C. Antz and B. Fakler are in the Dept. of Physiology II, Univ. of Tübingen,Ob dem Himmelreich 7, 72074 Tübingen, Germany.
Fast inactivation of voltage-gated potassium (K_v) channels is the best understood gating transition in ion channels and is brought about by an NH₂-terminal domain (ball domain) of the channel's -subunit, which physically blocks the open pore. Recent analysis by nuclear magnetic resonance spectroscopy showed that ball domains from various K_v channels exhibit well-defined but distinct structures in aqueous solution.

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