Physiology Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

News Physiol Sci 13: 182-189, 1998;
1548-9213/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Caflisch, A.
Right arrow Articles by Ehrhardt, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Caflisch, A.
Right arrow Articles by Ehrhardt, C.
News in Physiological Sciences, Vol. 13, No. 4, 182-189, August 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

Computer-Aided Design of Thrombin Inhibitors

Amedeo Caflisch, Rudolf Wälchli and Claus Ehrhardt

A. Caflisch is in the Dept. of Biochemistry, University of Zurich, CH-8057 Zurich, Switzerland; R. Wälchli and C. Ehrhardt are at the Novartis Pharma, Inc., CH-4002 Basel, Switzerland.
Computer-aided ligand design is an active, challenging, and multidisciplinary research field that blends knowledge of biochemistry, physics, and computer sciences. Whenever it is possible to experimentally determine or to model the three-dimensional structure of a pharmacologically relevant enzyme or receptor, computational approaches can be used to design specific high-affinity ligands. This article describes methods, applications, and perspectives of computer-assisted ligand design.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online