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News Physiol Sci 13: 203-210, 1998;
1548-9213/98 $5.00
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News in Physiological Sciences, Vol. 13, No. 4, 203-210, August 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

Historical Perspectives

The Isolated Perfused Heart and Its Pioneers

Heinz-Gerd Zimmer

H.-G. Zimmer is Professor of Physiology and Chair, Carl-Ludwig-Institute of Physiology, Univ. of Leipzig, Liebigstrasse 27, D-04103 Leipzig, Germany.
Abstract

In 1866, Carl Ludwig together with Elias Cyon created the first isolated perfused frog heart preparation. Perfusion systems for the isolated mammalian heart were developed by H. Newell Martin in 1883 and by Oscar Langendorff in 1895. In its working mode, the isolated perfused rat heart was established in the 1960s.






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