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M. Horowitz is in the Division of Physiology, Hadassah School of Dental Medicine, The Hebrew University, 91120 Jerusalem , Israel.
The classical concept of heat acclimation is of an autonomically controlled array of integrative physiological processes, improving heat tolerance. New evidence suggests that a temporal interplay between opposing autonomic and peripheral cell-originated responses, switched on by heat and autonomic stimulation of the cell membrane, and a marked increase in the stock of the inducible 70-kDa heat shock protein contribute to widening of the thermoregulatory activity span.
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