Physiology Journal of Applied Physiology
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News Physiol Sci 13: 231-240, 1998;
1548-9213/98 $5.00
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News in Physiological Sciences, Vol. 13, No. 5, 231-240, October 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

Proteinase-Activated Receptors: New Functions for Old Enzymes

Stephan K. Böhm, Karen McConalogue, Wuyi Kong and Nigel W. Bunnett

S. K. Böhm, K. McConalogue, and W. Kong are in the Dept. of Surgery, and N. W. Bunnett is in the Dept. of Surgery and Physiology, University of California San Francisco, San Francisco, CA 94143–0660, USA.
Although proteases are traditionally viewed as degradative enzymes, characterization of a family of G protein-coupled receptors that are activated by proteolysis reveals a new role. Certain proteases function as signaling molecules that specifically regulate cells by cleaving and activating a family of proteinase-activated receptors.




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