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News Physiol Sci 13: 241-246, 1998;
1548-9213/98 $5.00
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News in Physiological Sciences, Vol. 13, No. 5, 241-246, October 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

Fluid Shear Stress Modulation of Gene Expression in Endothelial Cells

Martin Braddock, Jean-Luc Schwachtgen, Parul Houston, Marion C. Dickson, Michael J. Lee and Callum J. Campbell

M. Braddock, J.-L. Schwachtgen, P. Houston, M. C. Dickson, M. J. Lee, and C. J. Campbell are in the Vascular Diseases Research Unit, Glaxo-Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK.
The vascular endothelium, lining the blood vessel wall, is constantly exposed to wall shear stresses generated by flowing blood. Gene regulation, critical for endothelial cell function, depends on complex interactions at the promoter level and utilizes overlapping signal transduction cascades to activate the expression of genes involved in many biological processes.




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