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News Physiol Sci 13: 287-293, 1998;
1548-9213/98 $5.00
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News in Physiological Sciences, Vol. 13, No. 6, 287-293, December 1998
© 1998 Int. Union Physiol. Sci./Am. Physiol. Soc.

Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models

Gerald A. Grant, N. Joan Abbott and Damir Janigro

G. A. Grant and D. Janigro are in the Department of Neurological Surgery, University of Washington School of Medicine, 325 9th Ave., Seattle, WA 98104, USA; N. J. Abbott is in the Biomedical Science Division, King's College, London, UK.
Endothelial cells exposed to inductive central nervous system factors differentiate into a blood-brain barrier phenotype. The blood-brain barrier frequently obstructs the passage of chemotherapeutics into the brain. Tissue culture systems have been developed to reproduce key properties of the intact blood-brain barrier and to allow for testing of mechanisms of transendothelial drug permeation.




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