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Healing of Gastrointestinal Mucosa: Involvement of Polyamines

Leonard R. Johnson and Shirley A. McCormack

L. R. Johnson is the Thomas A. Gerwin Professor and Chairman, and S. A. McCormack is Associate Professor, Department of Physiology, The University of Tennessee College of Medicine, Memphis, TN 38163, USA.
Polyamines are involved in the processes of cell migration and proliferation that result in the repair of mucosal lesions. Depletion of polyamines dramatically alters the arrangement of the cytoskeleton, EGF receptor function, the activities of signal transduction proteins, the levels of several protooncogenes, and the expression and cellular content of at least one growth factor involved in these processes.

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