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Chemosensory Perception in the Gut

Dirk Höfer, Esther Asan and Detlev Drenckhahn

D. Höfer, E. Asan, and D. Drenckhahn are in the Institute of Anatomy, Julius Maximilians University, Koellikerstr. 6, D-97070 Würzburg, Germany.
The ability of the gut mucosa to sense the chemical composition of chyme is important for gastrointestinal functions. The demonstration of gustducin and transducin, two -subunits of GTP-binding proteins involved in gustatory signal transduction, in gastrointestinal epithelial cells provides first clues to the molecular basis of enteric chemosensitivity. Nitric oxide may play a role as a secondary messenger.

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